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Author Topic: How can I detect Z-DNA with 3DNA?  (Read 16152 times)

Offline Valentina

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How can I detect Z-DNA with 3DNA?
« on: September 07, 2016, 08:12:03 am »
Hi everyone,

I tried to find the answer in the documentation but I'm a bit confused.
How can I detect the occurrence of Z-DNA in my sequences (that vary widely in length)? I'm interest in detecting the base positions of Z-DNA within the sequences.
Which commands should I use? And how should the input file be formatted?

Thank you for your time,
Valentina

Offline xiangjun

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Re: How can I detect Z-DNA with 3DNA?
« Reply #1 on: September 07, 2016, 08:51:27 am »
Hi Valentina,

3DNA is 3D-structure based, i.e., it starts from a tertiary structure in PDB format. So it is not designed to detect Z-DNA from base sequence alone. Other sequence-based tools may better fit your purpose.

Best regards,

Xiang-Jun

 

Funded by the NIH R24GM153869 grant on X3DNA-DSSR, an NIGMS National Resource for Structural Bioinformatics of Nucleic Acids

Created and maintained by Dr. Xiang-Jun Lu, Department of Biological Sciences, Columbia University