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General discussions (Q&As) / Questions about 3DNA
« on: October 16, 2026, 04:04:10 am »
Dear Dr. Xiang-Jun Lu,
First, of all thank you for accepting me in the forum and for your work. Could you please tell me where I can download the 3DNA v2.4 to perform structural analysis of nucleic acids? (academic research)
I would also like to ask you a more specific question. I am analyzing a modified base pair (completely different from WC bp), and when trying to determine the base-step parameters using nastruct, I obtain some artifacts (especially in the twist) due to the structural flexibility of the pair. I belive the best option would be to use the so-called simple helical parameters, based on consecutive C1'-C1' vectors. However, the problem is how to make the program recognize these non-natural bases. Is there any way to force the program to recognize them?
Thank you very much in advance for your help
First, of all thank you for accepting me in the forum and for your work. Could you please tell me where I can download the 3DNA v2.4 to perform structural analysis of nucleic acids? (academic research)
I would also like to ask you a more specific question. I am analyzing a modified base pair (completely different from WC bp), and when trying to determine the base-step parameters using nastruct, I obtain some artifacts (especially in the twist) due to the structural flexibility of the pair. I belive the best option would be to use the so-called simple helical parameters, based on consecutive C1'-C1' vectors. However, the problem is how to make the program recognize these non-natural bases. Is there any way to force the program to recognize them?
Thank you very much in advance for your help