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Author Topic: Figure 6. Molecular images of multiplets with two or more modes of G·A  (Read 37 times)

Offline shuxiang

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Figure 6. Molecular images of multiplets with two or more modes of G·A pairing in the complex of tetracycline with the U1052G-mutated 70S Escherichia coli ribosome.(69) Loops incorporating m–M sheared pairs are linked by different associations of G and A (highlighted within boxes) to other secondary structural units. A local representation of the linked bases is shown below each global depiction of associated secondary structures. Examples include (a) tetraplex with m+m pairing between a hairpin loop and a double-helical stem, (b) tetraplex with m+m pairing between an internal loop and a double-helical stem, (c) pentaplex with m+W pairing between a hairpin loop and a double-helical stem that is linked in turn to a junction, (d) tetraplex with m–m link pairing between an internal loop and a 5-way junction, (e) triplex with m–W pairing between a hairpin loop and a 3-way junction, and (f) pentaplex with .–M and m–W pairing within a 7-way junction. G·A pairs and secondary structural motifs are color-coded as in Figure 2. See Table S3 for respective Protein Data Bank identifiers, chain names, and residue numbers of depicted G·A-linked multiplets. Color-coding of bases and hydrogen bonds matches that in the corresponding secondary structural diagrams in Figure S8.

 

Created and maintained by Dr. Xiang-Jun Lu [律祥俊], Principal Investigator of the NIH grant R01GM096889
Dr. Lu is currently affiliated with the Bussemaker Laboratory at the Department of Biological Sciences, Columbia University.