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Messages - panosk

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General discussions (Q&As) / Tolerance of mutate_bases
« on: November 05, 2016, 12:53:08 pm »
Dear mr. Xiang-Jun,

I am a Bioinformatics graduate student and I am trying to construct an RNA structure because there
is not an available experimentally derived one. I have found a similar structure and I want to use mutate_bases
to change some of the bases. Also, I intend to perform energy minimization to the resulting structure after the changes.

I would like to know about the limits of this strategy. I wondered if there are areas in the structure
that are "more sensitive" to such changes.  Can I make consecutive mutations? Can I change a big area?

Thank you in advance.


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The Bussemaker Laboratory at the Department of Biological Sciences, Columbia University.