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Questions and answers => General discussions (Q&As) => Topic started by: akalantzi on November 05, 2014, 10:43:22 am

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Title: phenanthrene base
Post by: akalantzi on November 05, 2014, 10:43:22 am

Dear Xiangjun,

Is it possible with 3DNA to build a DNA that has phenanthrene bases?

Thanks in advance,
Alex

Title: Re: phenanthrene base
Post by: xiangjun on November 05, 2014, 11:56:11 am

Hi Alex,

Could be specific with an example?

Xiang-Jun

Title: Re: phenanthrene base
Post by: akalantzi on November 06, 2014, 04:07:33 am

For example in this structure here: http://pdb.org/pdb/explore/explore.do?structureId=1S88# and in this image: http://onlinelibrary.wiley.com/store/10.1002/chem.201301983/asset/image_m/mcontent.gif?v=1&s=fd3fa1ad5040d701d98b508b9f78f00ff177af0d There are bases with 3 rings. The pdb id is 2DM.

Title: Re: phenanthrene base
Post by: xiangjun on November 06, 2014, 09:43:15 am

Quote

Is it possible with 3DNA to build a DNA that has phenanthrene bases?

No. 3DNA does not take phenanthrene as a base at all.

You may find NAB from the the Case lab helpful.

Xiang-Jun

Title: Re: phenanthrene base
Post by: akalantzi on November 07, 2014, 04:30:56 am

I will check NAB. Thank you very much!

Created and maintained by Dr. Xiang-Jun Lu [律祥俊] (xiangjun@x3dna.org)
The Bussemaker Laboratory at the Department of Biological Sciences, Columbia University.