3DNA Forum

Questions and answers => General discussions (Q&As) => Topic started by: ara on July 26, 2013, 05:17:07 pm

Title: old Curves?
Post by: ara on July 26, 2013, 05:17:07 pm: Dear 3DNA community,

I know this is a 3DNA forum, however, I have a question about Curves. I did not find any Curves forum and I really like this forum and found it helpful in many ways.
I am analyzing DNA bending from molecular dynamics trajectories based on crystal structure of a drug-DNA complex. The crystal structure DNA bending was calculated with the old Curves program (Curves 5.2). I wanted to also use this old Curves for calculating DNA bending but I could not find it online. I do see some research groups that use both Curves and Curves+ to compare their results (A measure of bending in nucleic acids structures applied to A-tract DNA. F. Lankaš, N. Špačková, [...], and J. Šponer. Nucleic Acids Res. 2010 June; 38(10): 3414–3422). So i was wondering if anyone is aware if the old Curves is still available? Or currently there is only Curves+?

Thank you in advance,

Ara
Title: Re: old Curves?
Post by: xiangjun on July 26, 2013, 08:16:59 pm: Hi Ara,

Thanks for posting on the 3DNA Forum; questions about Curve/Curves+ are certainly not out of topic here.

To get a copy of the "old Curves", did you contact the authors, especially Dr. Richard Lavery? Alternatively, you may check with Dr. Remo Rohs who (as I am aware of) is still using the 'old Curves' (see a recent paper from his lab, titled "DNAshape: a method for the high-throughput prediction of DNA structural features on a genomic scale (http://nar.oxfordjournals.org/content/41/W1/W56.full)").

Xiang-Jun
Title: Re: old Curves?
Post by: ara on July 27, 2013, 04:14:03 pm: Thank you Xiang-Jun!

I did contact Dr. Lavery, however have not heard back from him yet. And thank you for the information about Dr. Rohs!

Ara