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Questions and answers > General discussions (Q&As)
construct dna hairpin structure
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atyagiaa:
Hi,
I read the manual, and i am confused, how to start designing the hairpin structure for following sequence.
GGGAGACAAGGAAAATCCTTCAATGAAGTGGGTCTCCC
((((((((((((...)))))...........)))))))
But, I don't know from where to start, i read the manual and found it confusing to start it.
Please suggest tutorial, any help will be very helpful.
Thanks
xiangjun:
Hi,
Sorry to know that you "read the manual and found it confusing to start" "designing the hairpin structure" of your sequence. That's not a surprise since 3DNA/DSSR is not a tool designed for such modeling purpose. You may find the RNA-Puzzles project relevant: some of the tools reported there should get you started. For example, try RNAComposer.
Best regards,
Xiang-Jun
atyagiaa:
Thankyou for the reply,
I used the server and obtained RNA structure, now I need to modify this structure to DNA, can 3DNA help me to perform this step.
xiangjun:
Thanks for your follow-up.
3DNA should be of help in modifying an RNA structure into its DNA variant. There are several possibilities here. Please use a concrete example to illustrate what you want to achieve.
Xiang-Jun
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Created and maintained by Dr. Xiang-Jun Lu [律祥俊] (xiangjun@x3dna.org)
The Bussemaker Laboratory at the Department of Biological Sciences, Columbia University.